Abstract: A highly sensitive label-free immunosensor for the detection of HIV-1 is newly developed based on localized surface plasmon resonance (LSPR) method. Uniform nanopattern of circular Au-dots (10-20nm) was fabricated on indium tin oxide (ITO) coated glass substrate by simple electrochemical deposition method. The surface of Au nanopattern… Continue reading
Abstract: Dendritic cells (DC), which play a major role in development of cell-mediated immunity, represent opportunities to develop novel anti-HIV vaccines. Dendrimers have been proposed as new carriers to ameliorate DC antigen loading and in this way, we have determined the potential use of maltose decorated neutrally and positively charged G4… Continue reading
Abstract: Early detection of circulation tumor cells (CTCs) in breast cancer patients has great clinical relevance. Currently, immunomagnetic microparticles enriched assays require Fe3O4 inner cores, making it difficult to improve sensitivity. In this study, we prepared magnetic nanoparticles with carbon-coated pure iron (Fe@C) acted as the core,… Continue reading
Abstract: Femtoinjection has been proposed as a feasible approach for the targeted delivery of a decoy oligodeoxynucleotide (ODN) into a single ES cell for the study of transcription factor activity. Here, we evaluated the utility of decoy ODN delivery via femtoinjection in an ES cell model in which Venus fluorescent protein was expressed under… Continue reading
Abstract: The role of complement in idiosyncratic reactions to nanopharmaceutical infusion is receiving increasing attention. We discuss this in relation to nanopharmaceutical development and the possible use of complement inhibitors to prevent related adverse reactions. We further call on initiation of genetic association studies to unravel the… Continue reading
La Agencia Europea del Medicamento (EMA) y el Ministerio Japonés de Salud, Trabajo y Bienestar (MHLW) han lanzado una consulta pública a raíz del documento “Joint MHLW/EMA reflection paper on the development of block-copolymer-micelle medicinal products”. La fecha límite para enviar sus comentarios es el 1 de julio de 2013.
Abstract: Herein, we develop FePt@Fe2O3 core-shell magnetic nanoparticles as a T2 magnetic resonance (MR) imaging contrast agent as well as a drug carrier for potential cancer theranostic applications. The FePt@Fe2O3 core-shell nanoparticles are synthesized and then functionalized with polyethylene glycol (PEG). Folic acid (FA) is conjugated on… Continue reading
A finales de 2012 concluyó el proyecto NANOTHER, una investigación a nivel europeo que Gaiker ha liderado con el doble objetivo de desarrollar nanopartículas capaces de detectar la localización de tumores y de eliminar el correspondiente tumor, liberando de manera controlada el fármaco contenido en ellas.
El 4 de marzo del 2013 Grifols adquirió el 60% del capital de la biotecnológica vasca Progenika Biopharma por un importe de 37 millones de euros