Nanopores are an exciting class of single molecule nanosensors. For several years now, nanopore technology has been developed as a biosensor at the single-molecule resolution to detect an array of biomedical molecules, such as DNA, RNA, protein, biotoxin, and various nanopore projects have been funded to develop the next generation of DNA… Nanopores are an exciting class of single molecule nanosensors. For several years now, nanopore technology has been developed as a biosensor at the single-molecule resolution to detect an array of biomedical molecules, such as DNA, RNA, protein, biotoxin, and various nanopore projects have been funded to develop the next generation of DNA sequencing technology. The sensing principle is based on the resistive pulse technique – molecules are detected as they pass through a single nanopore since during translocation the molecules exclude ions and therefore modulate the current. In new work, researchers have demonstrated the single molecule detection of a wide range of proteins with solid state glass nanopores.
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