Abstract: Nanoparticles have unique capacities of interacting with the cellular machinery and enter cells. To be able to exploit this potential, it is essential to understand what controls the interactions at the interface between nanoparticles and cells: it is now established that nanoparticles in biological media are covered by proteins and… Continue reading
Category Archives: Nanomedicine Journal
Photoactivation of Gold Nanoparticles for Glioma Treatment – Accepted Manuscript
Abstract: Radiosensitization efficacy of gold nanoparticles (AuNPs) with low energy radiations (88keV) was evaluated in vitro and in vivo on rats bearing glioma. In vitro, a significant dose-enhancement factor was measured by clonogenic assays after irradiation with synchrotron radiation of F98 glioma cells in presence of AuNPs (1.9 and 15nm in… Continue reading
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Getting nano tattoos right—A checklist of legal and ethical hurdles for an emerging nanomedical technology – Accepted Manuscript
Abstract: The nano tattoo represents a nascent technology designed to be implanted in the skin to provide continuous and reliable glucose detection for diabetics. Its potential benefits are compelling not only for its ability to prevent diabetic complications and decrease related social costs, but also for its ease of use and relative patient-user… Continue reading
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Dendrimer-enabled DNA delivery and transformation of Chlamydia pneumoniae – Accepted Manuscript
Abstract: The chlamydiae are important human pathogens. Lack of a genetic manipulation system has impeded understanding of the molecular bases of virulence for these bacteria. We developed a dendrimer-enabled system for transformation of chlamydiae and used it to characterize the effects of inserting the C. trachomatis plasmid into C. pneumoniae,… Continue reading
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Lysyl oxidase like-2 reinforces unsatisfactory ossification induced by bone morphogenetic protein-2: relating nanomechanical properties and molecular changes – Accepted Manuscript
Abstract: Bone morphogenetic protein-2 (BMP2) is among the most popular anabolic agents and substantially increase bone volume related to enhanced osteoblast differentiation. Here we demonstrate a remarkable deterioration in the nanomechanical properties of mineralized tissue induced from osteoblasts solely by the function of BMP2. Mineralized… Continue reading
Osseointegration of titanium with an antimicrobial nanostructured noble metal coating – Accepted Manuscript
Abstract: Nanometer scale surface features on implants and prostheses can potentially be used to enhance osseointegration and may also add further functionalities, such as infection resistance, to the implant. In this study, a nanostructured noble metal coating consisting of palladium, gold and silver, never previously used in bone applications,… Continue reading